Flu vaccines may shrink tumors and boost cancer treatment #Article

Flu vaccines may shrink tumors and boost cancer treatment #Article

When it comes to cancer tumors, there are many factors that influence whether they will respond to treatment or not. One of those is whether the tumors are "hot" or "cold."

A new type of anticancer therapy has gained in popularity in recent years: immunotherapy. This form of treatment works by improving the body's own immune response to cancer tumors.

However, in order for the therapy to have a higher chance of working, the tumors must be "hot" tumors— that is, immune cells must be in them. If a tumor does not contain (enough) immune cells, or contains immunosuppressive cells, a "cold" tumor is called.

One question researchers have tried hard to answer is: How do we turn cold tumors into hot tumors that lead to immunotherapy?

A team of researchers from the Rush University Medical Center in Chicago, IL, may have now found an effective way to do just that by using inactivated flu viruses— essentially, flu vaccines — in experiments on the mouse model.

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Clinical trials are research studies of new drugs, new drug formulations or already approved medicines that are being tested in new / different ways to treat patients. These may include new doses of drugs or new ways of delivering the drugs (schedules). Strict guidelines refer to clinical trials. Its purpose is to help figure out if new cancer therapies are safe and effective or better than the (current) standard treatment. Several clinical trials are open for the treatment of breast cancer at Massachusetts General Hospital Cancer Center, using the latest in cancer treatments.

Each patient treated at the Breast Cancer Center has a multidisciplinary team of specialists who manage all aspects of their treatment. The Breast Cancer team is headed by Leif Ellisen, MD, PhD, Program Manager, and Beverly Moy, MD, MPH, Clinical Director and includes medical, radiation, and surgical oncologists, pathologists, imaging department leaders, cancer genetics experts, nutritionists, and physical therapists.

The researchers also noted that the delivery of the flu vaccine into a melanoma tumor on one side of the body of a mouse led not only to a reduction in the growth of the tumor injected, but also to a slower growth of another tumor on another side of the body that they had not injected.

The researchers have seen similar results in mouse models when administering the flu vaccine to metastatic triple-negative breast cancer tumors.

"These results suggest that both[ people] who respond and do not respond to other immunotherapies may eventually benefit from influenza vaccine injection into the tumor and may increase the small proportion of patients who are now long-term immunotherapy respondents," says Dr. Zloza.

"Since humans and mice are genetically identical about 95 percent, the hope is that this approach will work in patients, and the next step is to conduct clinical trials to test various factors," he concludes.

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Flu vaccines may shrink tumors and boost cancer treatment #Article Flu vaccines may shrink tumors and boost cancer treatment #Article Reviewed by Extremeworldinfo.com on January 13, 2020 Rating: 5

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